First contact may refer to:

In anthropology,

First contact (anthropology), a first meeting of two previously unknown cultures

''First Contact'' (documentary), a documentary by Bob Connolly and Robin Anderson

In science fiction,

First contact (science fiction), a common science-fictional theme about the first meeting between humans and aliens

''First Contact'', a science fiction story by Murray Leinster.

First Contact (''TNG'' episode), a fourth season episode of ''Star Trek: The Next Generation''

''Star Trek: First Contact'', the eighth feature film based on the Star Trek science fiction television series

In other fields,

"Episode 0: First Contact", a 2002 television special based on the Lupin III animated series

First contact (astronomy), the moment in astronomy during a transit or eclipse when the apparent positions of the two bodies first touch